Author

Sophie R. Thomson

Simons Initiative for the Developing BrainORCID 0009-0005-5287-1857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Callista B. HarperiD· 1 shared Danilo NegroiD· 1 shared David Jonathan PriceiD· 1 shared Emily K. OsterweiliD· 1 shared Helen Marshall· 1 shared Jennifer C. DarnelliD· 1 shared John O. MasoniD· 1 shared Ka Wan LiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Callista B. HarperORCID

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2 papers

Recent·Most cited

Developmental BiologyDevelopmentPeer-reviewedOct 26, 2026

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

Wai Kit Chan, Shibla Abdulla, Lusi Zhao…·John O. Mason

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.

2 citations

humanexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 7, 2022

Excess ribosomal protein production unbalances translation in Fragile X Syndrome

Sang S. Seo, Susana R. Louros, Natasha J. Anstey…·Emily K. Osterweil

The paper identifies excessive ribosomal protein translation as a key factor in Fragile X Syndrome by showing its role in disrupting synaptic protein translation and LTD.

DOI 10.1101/2022.04.07.487442

mouseproteomics

𝕏 PostBluesky