Zrinko Kozić

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.

ASD mutations in the ciliary gene CEP41 impact development of projection neurons and interneurons in a human cortical organoid model

The paper investigates how ASD mutations in CEP41 affect cortical neuron development in human organoids, finding altered cilia stability and changes in interneuron and projection neuron differentiation.

The Fragile X Messenger Ribonucleoprotein 1 regulates the morphology and maturation of human and rat oligodendrocytes

This study investigates the role of FMRP in oligodendrocyte maturation and myelination in human and rat models, finding shared defects in morphology and function.

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

This study shows that rats with Fragile X Syndrome exhibit impaired experience-dependent changes in hippocampal spatial activity and circuit function compared to wild-type rats.

Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism

The paper examines flight-freeze response imbalances in Nlgn3-/y rats, finding hyperexcitability in periaqueductal grey neurons linked to altered fear behaviors.

Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons

This study shows that Pax6 loss affects neurite extension, axon initial segment properties, and electrophysiological function in developing mouse prethalamic neurons.

PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

This study shows that Pax6 limits the competence of developing cortical progenitors to respond to morphogens, preventing inappropriate lineage generation.

Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrain.

The paper identifies developing interneurons as a potential target for autism genetic risk factors by analyzing human and rodent neural data.

LAB-AID (Laboratory Automated Interrogation of Data): an interactive web application for visualization of multi-level data from biological experiments

LAB-AID is an interactive web tool that visualizes and interrogates hierarchical biological experimental data to improve understanding and identify outliers and batch effects.

The role of the diencephalon in the guidance of thalamocortical axons in mice

This study investigates the role of the diencephalon in guiding thalamocortical axons in mice, finding that molecular cues in the thalamus are critical for proper topographic mapping.

Tissue-specific actions of Pax6 on proliferation-differentiation balance in the developing forebrain are Foxg1-dependent

The paper shows Pax6 has opposite effects on proliferation-differentiation balance in murine diencephalon and cortex, with Foxg1 mediating these differences.