Author

Henry C Hollis

Drexel University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Ron C. AnafiiD· 3 shared Ashish SharmaiD· 2 shared David A. A BennettiD· 2 shared Erik S. MusiekiD· 2 shared Patrick W. SheehaniD· 2 shared Vilas MenoniD· 2 shared Anthony J. VeltriiD· 1 shared Darshan SapkotaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Ron C. AnafiORCID

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3 papers

Recent·Most cited

Single-cell Transcriptomic Variance Analysis Reveals Intercellular Circadian Desynchrony in the Alzheimer's Affected Human Brain

Henry C Hollis, Anthony J. Veltri, Ksenija Korać, Vilas Menon, David A. A Bennett, Sean M. Ronnekleiv‐Kelly, Junhyong Kim, Ron C. Anafi

The paper introduces ORPHEUS, a method to quantify circadian desynchrony in single-cell data, finding reduced synchrony in AD-affected human brain excitatory neurons.

bioRxiv · Mar 25, 2026 · PreprintBioinformatics

A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or aging.

Patrick W. Sheehan, Stuart B. Fass, Darshan Sapkota, Sylvia Kang, Henry C Hollis, Jennifer H. Lawrence, Sohui Park, Ashish Sharma, Dorothy P. Schafer, Ron C. Anafi, Joseph D. Dougherty, John Denis Fryer, Erik S. Musiek

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

Nature Neuroscience · Oct 23, 2025Peer-reviewedNeuroscience

Reconstructed Cell-Type Specific Rhythms in Human Brain link Alzheimer's Pathology, Circadian Stress, and Ribosomal Disruption

Henry C Hollis, Ashish Sharma, Patrick W. Sheehan, Leonard B. Maggi, Jason D. Weber, Jan A. Hammarlund, David Alan Bennett, Vilas Menon, Erik S. Musiek, Ron C. Anafi

The paper estimates circadian phases in human brain cells using single-nucleus RNA sequencing and finds disrupted ribosomal rhythms in Alzheimer's patients.

Neuron · Aug 6, 2025Peer-reviewedBioinformatics