This study integrates multi-omic data from mouse and human choroid plexus to identify conserved molecular programs of epithelial function across species.

bioRxiv · Oct 12, 2026 · PreprintNeuroscience

Circadian misalignment underlies immune escape in breast cancer

Chuqian Liang, Zunpeng Liu, Xiaoke Xu, Zhen Xu, Qi Zhang, Tao Zhang, Riley J. Mangan, Bingqiu Xiu, Gongwei Wu, Tara K. Akhshi, Zachary M. Sandusky, G. Kenneth Gray, Na Zhang, Genevra M. Kuziel, Nicole A. Traphagen, , Myles Brown

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

bioRxiv · May 29, 2026 · PreprintCancer Biology

A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or aging.

Patrick W. Sheehan, Stuart B. Fass, Darshan Sapkota, Sylvia Kang, Henry C Hollis, Jennifer H. Lawrence, Sohui Park, Ashish Sharma, Dorothy P. Schafer, Ron C. Anafi, Joseph D. Dougherty, John Denis Fryer, Erik S. Musiek

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

Nature Neuroscience · Oct 23, 2025Peer-reviewedNeuroscience

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease

Stuart B. Fass, Bernard Mulvey, Rebecca Chase, Wei Cheng Yang, Din Selmanovic, Sneha M. Chaturvedi, Eric Tycksen, Lauren A. Weiss, Joseph D. Dougherty

The paper examines sex biases in gene expression across brain regions and links them to sex differences in autism and Alzheimer's disease prevalence.

Biology of Sex Differences · Jun 6, 2024Peer-reviewedGenetic & Genomic Medicine

Evaluation of gliovascular functions of Aqp4 readthrough isoforms

Shayna M. Mueller, Kelli McFarland White, Stuart B. Fass, Siyu Chen, Zhan Shi, Xia Ge, John A. Engelbach, Seana H Gaines, Annie R. Bice, Michael J. Vasek, Joel Richard Garbow, Joseph P. Culver, Zila Martínez‐Lozada, Martine Cohen‐Salmon, Joseph D. Dougherty, Darshan Sapkota

This study evaluates the role of AQP4 readthrough isoforms in gliovascular functions using a novel mouse model and finds that AQP4x modulates BBB integrity and protein localization.

Frontiers in Cellular Neuroscience · Nov 23, 2023Peer-reviewedNeuroscience

A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo

Tomás Lagunas, Stephen P. Plassmeyer, Anthony D. Fischer, Ryan Z. Friedman, Michael A. Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K Sol, Michael J. Kasper, Stuart B. Fass, Alessandra F. Aguilar Lucero, Joon‐Yong An, Stephan Sanders, Barak A. Cohen, Joseph D. Dougherty

The paper develops a method to assess the functional effects of non-coding elements in specific cell types in vivo using a Cre-dependent MPRA approach.

Communications Biology · Nov 12, 2023Peer-reviewedGenetics

Typical hippocampal transcriptional response across estrous is dysregulated by Cnih3 gene deletion

Bernard Mulvey, Hannah E. Frye, Tania Lintz, Stuart B. Fass, Eric Tycksen, Elliot C. Nelson, José A. Morón, Joseph D. Dougherty

The paper profiles hippocampal transcriptomes across estrous cycles in mice, identifies estrous-responsive genes, and shows Cnih3 deletion disrupts estrous-specific gene expression patterns.

bioRxiv · Apr 11, 2022 · PreprintNeuroscience