Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer
Nicole A. Traphagen, Esmé Wheeler, Rong Li, Tara K. Akhshi, Ramya Ravindranathan, Christian Alfieri, Feng Lu, Buraq Ahmed, Alok K. Tewari, Steven P. Balk, Peter S. Nelson, Eva Corey, Henry Long, Alan D. D’Andrea, Xintao Qiu, Myles A Brown
This study shows that AR inhibition does not enhance PARP inhibitor efficacy in HR-proficient prostate cancer and instead impairs response in castration-sensitive cells.
Proceedings of the National Academy of Sciences · Jan 27, 2026Peer-reviewedCancer Biology