Ramya Ravindranathan

This paper identifies a PIP motif in RAD18 essential for PCNA ubiquitination and shows USP1 inhibition leads to synthetic lethality in BRCA1-deficient cells.

This study shows that AR inhibition does not enhance PARP inhibitor efficacy in HR-proficient prostate cancer and instead impairs response in castration-sensitive cells.

This study identifies the CHAMP1 complex as a regulator of heterochromatin assembly and replication fork stability, showing its role in preventing genomic instability in cancer cells.