Author

Hilal A. Lashuel

Ecole Polytechnique Federale de Lausanne (EPFL);

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alex Matthewson· 1 shared Anne-Laure Mahul Mellier· 1 shared Anne-Laure Mahul-Mellier· 1 shared Anton Schuele· 1 shared Carl Ash· 1 shared Caroline A. Cuoco· 1 shared Christian M. ColeiD· 1 shared Christina Ulrich· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMolecular Biology

Alex Matthewson

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Aggregate Deep Visual Proteomics reveals selective organization of α-synuclein inclusions

Marc Oeller, Sabine Vasconez Grunauer, Cole S Sitron, Anne-Laure Mahul Mellier, Lucas Diedrich, Anton Schuele, Viktoria Ruf, Denys Oliinyk, Fabien Kuttler, Ulrich Dransfeld, Jana Prassler, Shani Ben-Moshe, Edwin Rodriguez, Tim Heymann, Enes Ugur, , Matthias Mann

This study uses Aggregate Deep Visual Proteomics to show that α-synuclein inclusions selectively concentrate specific proteins in neurons, revealing their formation mechanisms and potential therapeutic targets.

bioRxiv · Nov 3, 2026 · PreprintBiochemistry

Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes

Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier, Yuting Zhang, Patricia Martinez-Botia, Sergio R. Labra, Lynee A. Massey, Zi Gao, Zainab Ahmed, Karina Nugroho, Carl Ash, Wen Ren, Christian M. Cole, Yin Wu, Sarah Ly, , Jeffery W. Kelly

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology