Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids
Maria I. Olivero-Acosta, Morgan J. Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, C. Max Otterbacher, Hina Kadono, Manasi Suchit Halurkar, Harish Kothandaraman, Nadia A. Lanman, Trang Nguyen, , Yang Yang
This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.
Epilepsia · Jul 30, 2026Peer-reviewedNeuroscience