Author

Benjamin Zirkle

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. Max OtterbacheriD· 2 shared Chongli YuaniD· 2 shared Hope Elizabeth Harlow· 2 shared Jingliang ZhangiD· 2 shared Kyle W. WettschurackiD· 2 shared Manasi Suchit HalurkariD· 2 shared Maria I. Olivero-AcostaiD· 2 shared Morgan J. RobinsoniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

C. Max OtterbacherORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

Maria I. Olivero-Acosta, Morgan J. Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, C. Max Otterbacher, Hina Kadono, Manasi Suchit Halurkar, Harish Kothandaraman, Nadia A. Lanman, Trang Nguyen, , Yang Yang

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

Epilepsia · Jul 30, 2026Peer-reviewedNeuroscience

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

Zhefu Que, Maria I. Olivero-Acosta, Morgan J. Robinson, Ian Chen, Jingliang Zhang, Kyle W. Wettschurack, Jiaxiang Wu, Tiange Xiao, C. Max Otterbacher, Vinayak Shankar, Hope Elizabeth Harlow, Seoyong Hong, Benjamin Zirkle, Muhan Wang, Ningren Cui, , Yang Yang

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

Journal of Neuroscience · Nov 18, 2024Peer-reviewedNeuroscience