ALKBH1 drives codon-biased, pro-oncogenic translation and tumor microenvironment remodeling in glioma via tRNA wobble oxidation
Atsushi Nakayashiki, Arata Nagai, Yuko Iwasaki, Abdulrahman Mousa, Moe Kumai, Munehiro Kimura, Shadi Al-Mesitef, Hiroshi Kanno, Shota Yamashita, Daisuke Ando, Yoshiteru Shimoda, Masayuki Kanamori, Keisuke Goda, Hidenori Endo, Sherif Rashad, Kuniyasu Niizuma
This study identifies ALKBH1 as a driver of codon-biased translation and tumor microenvironment remodeling in glioma, promoting stemness and immune evasion.
bioRxiv · Nov 28, 2025 · PreprintCancer Biology