HIF isoforms contribute distinctly during human NK cell activation
Jorrit De Waele, Tias Verhezen, Ho Wa Lau, Jöran Melis, Louize Brants, Jonas R.M. Van Audenaerde, Julie de Beukelaar, Charlotte Gevaerts, Filip Lardon, An Wouters, Evelien Smits
This study investigates the distinct roles of HIF-1 and HIF-2 in human NK cell activation under normoxic conditions, finding that HIF-1 inhibition reduces cytotoxicity and cytokine production while HIF-2 has no effect.
bioRxiv · Jun 27, 2025 · PreprintImmunology