Humanization of N-glycan-dependent protein quality control system in Kluyveromyces marxianus promotes glycoprotein secretion
Yi Ai, Yuting He, Lunqiang Zhao, Miaomiao Li, Yongming Wang, Jungang Zhou, Hong Lu, Yao Yu
The paper enhances glycoprotein secretion in yeast by engineering a human-like protein quality control system, resulting in up to 12-fold increased production of therapeutic glycoproteins.
Metabolic Engineering · Jul 31, 2026Peer-reviewedBioengineering