Cell-Autonomous AR Dependence in Luminal Prostatic Epithelium Governs Survival and Lineage Plasticity
Dan Li, Naitao Wang, Wangxin Guo, Jude N. Owiredu, Woo Hyun Cho, Dana Schoeps, Shipeng Cheng, Hongjiong Zhang, Un In Chan, Chen Khuan Wong, V.R. Callychurn, Hongsu Wang, Wenfei Kang, Ning Fan, Hilda Amalia Pasolli, , Yu Chen
This study shows that luminal prostatic epithelial cells depend on AR signaling for survival and differentiation, and their loss triggers compensatory pathways and lineage plasticity.
bioRxiv · Feb 16, 2026 · PreprintCell Biology