Huan Li

Endothelin 2-Mediated Neuroinflammation Drives Hypertension-Associated Retinal Dysfunction

This study shows that endothelin-2 drives hypertension-related retinal dysfunction through neuroinflammation, independent of intraocular pressure, and identifies EDNRA as a therapeutic target.

Widespread Recruitment of ParA-like NTPases into Prokaryotic Immunity reveals a diversity of anti-selfish element strategies

The paper identifies ParA-like NTPases as key components in prokaryotic immunity, revealing diverse strategies to combat selfish genetic elements.

Validation of MHPC512: A Publicly Available Special-Purpose Supercomputer for Molecular Dynamics Simulations of Biomolecular Systems

The paper validates MHPC512, a special-purpose supercomputer for molecular dynamics simulations, showing it produces results consistent with established software.

Flytrap-Inspired Mesh-Trap Bioelectronics for Full Spherical Electrophysiological Interrogation of 3D Tissues

This paper introduces a bioelectronic mesh system for comprehensive electrophysiological monitoring of 3D tissues and assembloids, enabling long-term stable recordings and high-throughput analysis.

The amplitude and latency of the earliest signal in V1 encode bottom-up saliency by feature conjunction

The paper shows that early V1 neural signals encode bottom-up saliency based on feature conjunction, with latency and amplitude predicting behavioral performance.

Iterative delivery of mRNA by MEFI

This paper introduces MEFI, a platform for iterative mRNA delivery that enhances expression and cross-organ transfer in mice.

The response of ETV6-NTRK3 condensates to TRK inhibitors elucidates their precise phase separationmechanism

This study investigates how TRK inhibitors affect ETV6-NTRK3 condensates, revealing a liquid-to-solid transition and a new phase separation model.

Salidroside Mitigates Malignant Arrhythmias by Restoring Sodium Channel Function During Ultra-Acute Myocardial Infarction

This paper shows Salidroside reduces malignant arrhythmias in AMI by restoring sodium channel function and improving conduction uniformity.

Complex Interplay between Serum and Fibroblasts in 3D Hepatocyte Co-culture

This study examines how combining 3D hepatocyte spheroid culture with fibroblast co-culture and serum affects hepatocyte function, finding that serum enhances cytochrome activity in co-cultures but not in monocultures.

A mechanistic model of linkage analysis in allohexaploids

This paper develops a computational framework for linkage analysis in allohexaploids by integrating meiotic pairing mechanisms into a mixture model, validated through simulations and real data.