DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides
Qian Ren, Jing Wang, Vinay Kumar Idikuda, Shanwen Zhang, Jeehae Shin, W. Grant Ludlam, Luis M. Real Hernandez, Sara Zdancewicz, Alex J.B. Kreutzberger, Hucheng Chang, Volker Kiessling, Lukas K. Tamm, Ahmad Jomaa, Ilya Levental, Kirill A. Martemyanov, , Huan Bao
This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.
Nature Communications · Aug 26, 2025Peer-reviewedBiophysics