Bernard Fromenty

This study identifies PPARgamma as a key regulator of metabolic reprogramming and stemness in hepatic CSCs, linking it to chemoresistance in HCC.

This study shows that maneb and mancozeb disrupt lipid and xenobiotic metabolism in HepaRG cells, especially when exposed to fatty acids.

This study shows that increased CYP2E1 activity from fatty acids in HepaRG cells does not always lead to greater acetaminophen toxicity, as only certain fatty acids exacerbate liver damage.

This paper introduces a strategy to detect metabolic changes from chemical exposure using transcriptomics data and metabolic models, identifying potential mechanisms of action in vitro.