A compact Druantia defense clears phage infections via single-stranded DNA recognition and directional duplex unwinding
Stephanie Himpich, Thomas Gaudin, Lena M. Grass, Huihui Li, Vu Van Loi, Chao Chen, Eberhard Klauck, Philipp F. Popp, Maximilian Feussner, Benno Kuropka, Tarek Hilal, Bernhard Loll, Marc Erhardt, Haike Antelmann, Chase L. Beisel, Markus C. Wahl
This paper describes how the Druantia type III-A defense system in E. coli clears phage infections by recognizing single-stranded DNA and unwinding DNA duplexes directionally.
Cell Reports · Sep 22, 2026Peer-reviewedMicrobiology