Author

Thomas Gaudin

Helmholtz Centre for Infection Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chase L. BeiseliD· 2 shared Benno KuropkaiD· 1 shared Bernhard LolliD· 1 shared Chao Chen· 1 shared Eberhard Klauck· 1 shared Eugene V. KooniniD· 1 shared Franklin L. NóbregaiD· 1 shared Haike AntelmanniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Chase L. BeiselORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A compact Druantia defense clears phage infections via single-stranded DNA recognition and directional duplex unwinding

Stephanie Himpich, Thomas Gaudin, Lena M. Grass, Huihui Li, Vu Van Loi, Chao Chen, Eberhard Klauck, Philipp F. Popp, Maximilian Feussner, Benno Kuropka, Tarek Hilal, Bernhard Loll, Marc Erhardt, Haike Antelmann, Chase L. Beisel, Markus C. Wahl

This paper describes how the Druantia type III-A defense system in E. coli clears phage infections by recognizing single-stranded DNA and unwinding DNA duplexes directionally.

Cell Reports · Sep 22, 2026Peer-reviewedMicrobiology

YprA family helicases provide the missing link between diverse prokaryotic immune systems

Ryan T. Bell, Thomas Gaudin, Yi Wu, Sofya K. Garushyants, Harutyun Sahakyan, Kira S. Makarova, Yuri I. Wolf, Simon A. Jackson, Franklin L. Nóbrega, Chase L. Beisel, Eugene V. Koonin

The paper identifies YprA family helicases as a missing link connecting DISARM and Druantia immune systems in prokaryotes, revealing new defense classes and their antiviral mechanisms.

Cell Host & Microbe · Jun 11, 2026Peer-reviewedMicrobiology