Tarek Hilal

Molecular mechanism of albicidin-dependent transcription activation by the antibiotic resistance factor AlbA

This study elucidates how AlbA, an antibiotic resistance factor, activates transcription in response to albicidin by remodeling promoter architecture and facilitating a kinetic transition to promoter opening.

A compact Druantia defense clears phage infections via single-stranded DNA recognition and directional duplex unwinding

This paper describes how the Druantia type III-A defense system in E. coli clears phage infections by recognizing single-stranded DNA and unwinding DNA duplexes directionally.

Regulatory landscapes and structural choreography of transcription initiation in spirochetes

This study investigates the transcription initiation mechanism in spirochetes, revealing unique structural and functional features of their RNA polymerase.

Widespread gene regulator Psu inhibits transcription termination factor rho by forced hyper-oligomerization