Author

Huiyun Liu

Dana-Farber Cancer InstitutePrimary ORCID profile (0009-0002-7483-8570 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Huiyun LiuiD1 paper · Dana-Farber Cancer Institute

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam LangenbucheriD· 1 shared Austin Injae KimiD· 1 shared Bin TianiD· 1 shared Christine E. RyaniD· 1 shared Claire L. MooreiD· 1 shared David M. WeinstockiD· 1 shared Ehsan Ranaei PirmardaniD· 1 shared Emily SumpenaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adam LangenbucherORCID

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2 papers

Recent·Most cited

Targeting CPSF73, the mRNA 3' End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State

Marzieh Naseri, Huiyun Liu, Luyang Wang, Salwa Mohd Mostafa, Ehsan Ranaei Pirmardan, Bin Tian, Claire L. Moore

This study shows that inhibiting CPSF73, an mRNA 3' end processing enzyme, reduces cancer cell proliferation and reverses the mesenchymal state by altering alternative polyadenylation (APA) patterns and 3'UTR lengths in multiple cancer cell lines.

Frontiers in Immunology · Aug 5, 2026Peer-reviewedCancer Biology

Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma

Ye Zhang, Lydie L. Debaize, Adam Langenbucher, Jenalyn Weekes, Ioulia Vogiatzi, Teemu P. Miettinen, Mingzeng Zhang, Emily Sumpena, Huiyun Liu, Sarah Marie Duquette, Liam R. Hackett, Jeremy Zhang, Sona Baghiyan, Robert Allyn Redd, Martin J. Aryee, , Mark Alan Murakami

This study integrates single-cell biophysical and transcriptomic data to identify clinically relevant phenotypes in mantle cell lymphoma, linking biophysical properties to gene expression and drug response.

Science Advances · Dec 5, 2025Peer-reviewedCancer Biology