Luyang Wang

This study shows that inhibiting CPSF73, an mRNA 3' end processing enzyme, reduces cancer cell proliferation and reverses the mesenchymal state by altering alternative polyadenylation (APA) patterns and 3'UTR lengths in multiple cancer cell lines.

This study identifies drug-tolerant persister states in melanoma using MeRLin, showing their role in resistance and tumor recurrence.

This study shows that CFIm25 promotes macrophage differentiation by enhancing alternative polyadenylation and activating the NF-κB pathway.

CRISPRpas regulates alternative polyadenylation by dCas9, altering PAS usage and demonstrating its impact on gene expression and APA-related SNPs.