Claire L. Moore

Targeting CPSF73, the mRNA 3' End Processing Endonuclease, Moves Cancer Cells Away from the Mesenchymal State

This study shows that inhibiting CPSF73, an mRNA 3' end processing enzyme, reduces cancer cell proliferation and reverses the mesenchymal state by altering alternative polyadenylation (APA) patterns and 3'UTR lengths in multiple cancer cell lines.

CFIm25-Dependent Alternative Polyadenylation in AKT2 mRNA Programs Macrophage Polarization

This study shows CFIm25 regulates macrophage polarization by controlling AKT2 mRNA polyadenylation, promoting M1 traits and suppressing M2 features.

The Alternative Polyadenylation Factor CFIm25 Orchestrates Macrophage Antibacterial Immunity by Amplifying TAB2-Mediated MAPK and NF-κB Signaling During Salmonella Infection

This study shows CFIm25 enhances macrophage antibacterial immunity against Salmonella by regulating alternative polyadenylation and boosting MAPK and NF-κB signaling.

Alternative Polyadenylation Releases PCBP1-Mediated Suppression of CFIm25 During Macrophage Differentiation

The paper shows that alternative polyadenylation of CFIm25 mRNA removes PCBP1 binding during macrophage differentiation, increasing CFIm25 protein and promoting differentiation markers.

RNA Alternative Splicing and Polyadenylation and Regulation of the Glomerular Filtration Barrier

This study identifies altered alternative splicing and polyadenylation in glomerular genes during kidney disease models and demonstrates potential therapeutic modulation using antisense oligonucleotides.

The alternative polyadenylation regulator CFIm25 promotes macrophage differentiation and activates the NF-κβ pathway

This study shows that CFIm25 promotes macrophage differentiation by enhancing alternative polyadenylation and activating the NF-κB pathway.

Macrophage differentiation is marked by increased abundance of the mRNA 3' end processing machinery, altered poly(A) site usage, and sensitivity to the level of CstF64

This study shows that macrophage differentiation involves changes in mRNA polyadenylation, poly(A) site usage, and sensitivity to CstF64, a cleavage/polyadenylation protein.