Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman, Giuseppe Galleti, Chao Wu, Vinagolu K. Rajasekhar, HyoKyeong Cha, Deniz Ata, Jongjin Kim, Taylor Weisskittel, Mame Diop, Thiri Aung, Michael Del Latto, Amanda S. Kim, Zhuoning Li, , Kitai Kim
The paper investigates how aging-dependent dysregulation of EXOSC2 affects cellular traits and finds that PPP2R5E, a PP2A phosphatase subunit, is a key target of EXOSC2, with this regulation maintained in stem cells and cancer.
bioRxiv · Apr 4, 2025 · PreprintCell Biology