Author

I. Doel-Perez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Stockinger· 3 shared J. B. Huppa· 3 shared J. Gohring· 2 shared M. Hudecek· 2 shared R. Platzer· 2 shared A. Plach· 1 shared B. Salzer· 1 shared C. Bodner· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

H. Stockinger

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3 papers

Recent·Most cited

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

T. Peters, V. Muehlgrabner, R. M. H. Velasco Cardenas, R. Platzer, J. Gohring, B. Salzer, A. Plach, M. Hoehrhan, I. Doel-Perez, V. D. R. Goncalves, J. S. Farfan, M. Lehner, H. Stockinger, W. W. Schamel, K. Schober, , J. B. Huppa

This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.

bioRxiv · Mar 16, 2023 · PreprintImmunology

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion

R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa

The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.

bioRxiv · Mar 13, 2023Immunology

Inefficient ZAP70-Signaling Blunts Antigen Detection by CAR-T-Cells

V. Gudipati, J. Rydzek, I. Doel-Perez, L. Scharf, S. Königsberger, H. Einsele, H. Stockinger, M. Hudecek, J. B. Huppa

This study identifies that inefficient ZAP70 signaling in CAR-T-cells reduces antigen detection sensitivity compared to TCRs.

bioRxiv · Jul 30, 2019Immunology