Author

H. Einsele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Hudecek· 3 shared A. Beilhack· 1 shared A. Ghosh· 1 shared A.-L. Jordan-Garrote· 1 shared B. Arslan· 1 shared C. Brede· 1 shared C. Miskey· 1 shared C. R. Thornton· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

M. Hudecek

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

L. Heilg, F. Natasha, N. Trinks, V. K. AIMANIANDA BOPAIAH, S. Sze Wah Wong, T. Fontaine, U. Terpitz, L. Strobel, F. Le Mauff, D. Sheppard, S. Schaeuble, O. Kurzai, K. Huenniger, E. Weiss, M. Vargas, , J. Loeffler

This study identifies galactosaminogalactan as the fungal ligand for CD56 on human NK cells, triggering antifungal responses and immune cell activation.

bioRxiv · Aug 18, 2023 · PreprintMicrobiology

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

C. Verbruggen, L. Gehrke, N. Banholzer, A. Ghosh, S. Reinhard, J. Weber, S. Doose, H. Einsele, M. Hudecek, T. Nerreter, M. Sauer

This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.

bioRxiv · Jul 19, 2023 · PreprintImmunology

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

C. Miskey, M. Amberger, M. Reiser, S. Prommersberger, J. Beckmann, M. Machwirth, H. Einsele, M. Hudecek, H. Bonig, Z. Ivics

This paper characterizes the genomic safety of SLAMF7 CAR-T cells produced using Sleeping Beauty transposon technology for multiple myeloma treatment, showing safe integration and no residual transposase.

bioRxiv · Aug 27, 2019 · PreprintBioengineering

Inefficient ZAP70-Signaling Blunts Antigen Detection by CAR-T-Cells

V. Gudipati, J. Rydzek, I. Doel-Perez, L. Scharf, S. Königsberger, H. Einsele, H. Stockinger, M. Hudecek, J. B. Huppa

This study identifies that inefficient ZAP70 signaling in CAR-T-cells reduces antigen detection sensitivity compared to TCRs.

bioRxiv · Jul 30, 2019Immunology

3D light sheet fluorescence microscopy of lungs to dissect local host immune - Aspergillus fumigatus interactions

J. Amich, Z. Mokhtari, M. Strobel, E. Vialetto, N. Kalleda, K. Jarick, C. Brede, A.-L. Jordan-Garrote, S. Thusek, K. Schmiedgen, B. Arslan, J. Pinnecker, C. R. Thornton, M. Gunzer, S. Krappmann, , A. Beilhack

This paper uses 3D light sheet fluorescence microscopy to analyze fungal growth and immune responses in murine models of invasive pulmonary aspergillosis, revealing differences in fungal architecture and immune cell interactions across immunosuppressive regimens.

bioRxiv · Jun 5, 2019Immunology