Author

E. Sevcsik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. J. Schuetz· 4 shared J. B. Huppa· 4 shared R. Platzer· 4 shared H. Stockinger· 3 shared J. Hellmeier· 3 shared M. Brameshuber· 3 shared E. Kurz· 2 shared M. C. Schneider· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBiophysics

G. J. Schuetz

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Author profile →

4 papers

Recent·Most cited

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion

R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa

The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.

bioRxiv · Mar 13, 2023Immunology

Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins

J. Hellmeier, R. Platzer, V. Muehlgrabner, M. C. Schneider, E. Kurz, G. J. Schuetz, J. B. Huppa, E. Sevcsik

This study evaluates strategies for site-specific decoration of DNA origami with functional proteins, finding that PNA-based conjugation best preserves protein function and stoichiometry.

bioRxiv · Jul 1, 2021Biophysics

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics

Unscrambling Fluorophore Blinking for Comprehensive Cluster Detection via Photoactivated Localization Microscopy

R. Platzer, B. K. Rossboth, M. C. Schneider, E. Sevcsik, F. Baumgart, H. Stockinger, G. J. Schuetz, J. B. Huppa, M. Brameshuber

The paper develops a method to quantify and correct for fluorophore blinking in PALM to improve cluster detection accuracy.

bioRxiv · May 30, 2020Biophysics