Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
D. Soll, M. Arunkumar, M. Alissa-Alkhalaf, S. Sun, T. Nguyen, C.-F. Chu, V. Lutz, S. Schauble, I. Garcia-Ribelles, M. Mueller, B. Michalke, G. Panagiotou, P. Schatzlmaier, H. Stockinger, W. Schamel, , C. E. Zielinski
This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.
bioRxiv · Sep 14, 2023Immunology
T. Peters, V. Muehlgrabner, R. M. H. Velasco Cardenas, R. Platzer, J. Gohring, B. Salzer, A. Plach, M. Hoehrhan, I. Doel-Perez, V. D. R. Goncalves, J. S. Farfan, M. Lehner, H. Stockinger, W. W. Schamel, K. Schober, , J. B. Huppa
This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.
bioRxiv · Mar 16, 2023 · PreprintImmunology
R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa
The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.
bioRxiv · Mar 13, 2023Immunology
A. Ohradanova-Repic, L. Gebetsberger, G. Tajti, G. Ondrovicova, R. Prazenicova, R. Skrabana, P. Barath, H. Stockinger, V. Leksa
This study identifies a lactoferrin-derived peptide that inhibits TMPRSS2-mediated SARS-CoV-2 spike protein processing and viral infection.
bioRxiv · Dec 20, 2021Immunology
R. Gawish, P. Starkl, L. Pimenov, A. Hladik, K. Lakovits, F. Oberndorfer, S. J. F. Cronin, A. Ohradanova-Repic, G. Wirnsberger, B. Agerer, L. Endler, T. Capraz, J. W. Perthold, A. Hagelkruys, N. Montserrat, , S. Knapp
This paper develops a mouse-adapted SARS-CoV-2 strain, maVie16, to model COVID-19 in mice, showing that ACE2 is critical for disease and that blocking TNF/IFNγ reduces immunopathology.
bioRxiv · Aug 9, 2021Immunology
J. Göhring, F. Kellner, L. Schrangl, R. Platzer, E. Klotzsch, H. Stockinger, J. B. Huppa, G. Schuetz
The paper measures T-cell receptor forces using single molecule FRET, finding a 5 pN force peak during T-cell activation on gel-phase SLBs.
Nature Communications · May 4, 2021Peer-reviewedBiophysics
J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik
The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.
Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics
R. Platzer, B. K. Rossboth, M. C. Schneider, E. Sevcsik, F. Baumgart, H. Stockinger, G. J. Schuetz, J. B. Huppa, M. Brameshuber
The paper develops a method to quantify and correct for fluorophore blinking in PALM to improve cluster detection accuracy.
bioRxiv · May 30, 2020Biophysics
V. Gudipati, J. Rydzek, I. Doel-Perez, L. Scharf, S. Königsberger, H. Einsele, H. Stockinger, M. Hudecek, J. B. Huppa
This study identifies that inefficient ZAP70 signaling in CAR-T-cells reduces antigen detection sensitivity compared to TCRs.
bioRxiv · Jul 30, 2019Immunology