Author

I. Gaska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Alfieri· 3 shared J. Al-Bassam· 2 shared J. Major· 2 shared L. Gheber· 2 shared S. Forth· 2 shared S. Inagaki· 2 shared S. T. Forth· 2 shared T. Bodrug· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

A. Alfieri

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multicomponent regulation of actin barbed end assembly by twinfilin, formin and capping protein

H. Ulrichs, I. Gaska, S. Shekhar

This study reveals how twinfilin, formin, and capping protein interact at actin barbed ends to regulate polymerization, showing twinfilin promotes formin-based elongation when CP is present.

bioRxiv · Apr 24, 2023Biophysics

The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization

S. Nithiananatham, M. K. Iwanski, I. Gaska, H. Pandey, T. Bodrug, S. Inagaki, J. Major, G. Brouhard, L. Gheber, S. S. Rosenfeld, S. T. Forth, A. G. Hendricks, J. Al-Bassam

This study investigates how the structural features of kinesin-5, specifically tail-motor domain interactions and minifilament length, influence microtubule sliding motility and spindle organization.

bioRxiv · Oct 12, 2021 · PreprintCell Biology

Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption

A. Alfieri, I. Gaska, S. Forth

This study identifies two distinct mechanical resistance modes of PRC1 in resisting kinesin-driven microtubule sliding, revealing cooperative clustering mechanisms.

bioRxiv · Aug 10, 2020Biophysics

The mitotic crosslinking protein PRC1 acts as a mechanical dashpot to resist microtubule sliding

I. Gaska, M. Armstrong, A. Alfieri, S. Forth

The paper measures the mechanical properties of PRC1, showing it generates velocity-dependent frictional forces that resist microtubule sliding, acting like a mechanical dashpot.

bioRxiv · Dec 12, 2019 · PreprintBiophysics

The Kinesin-5 Tail Domain Directly Modulates the Mechanochemical Cycle of the Motor for Anti-Parallel Microtubule Sliding

T. Bodrug, E. Wilson-Kubalek, S. Nithianantham, A. F. Thompson, A. Alfieri, I. Gaska, J. Major, G. Debs, S. Inagaki, P. Gutierrez, L. Gheber, R. McKenney, C. Sindelar, R. Milligan, J. Stumpff, , J. Al-Bassam

This study shows the kinesin-5 tail domain regulates motor activity by modulating ATP hydrolysis and microtubule sliding, leading to slow motility and force generation.

bioRxiv · Aug 8, 2019Biophysics