This paper adapts a transmitted/founder SHIV to enhance replication in rhesus macaques while preserving HIV-1 Env biology, resulting in a more fit virus for NHP HIV studies.

bioRxiv · Dec 12, 2022Microbiology

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

N. Suryadevara, A. Shiakolas, L. VanBlargan, E. Binshtein, R. Chen, J. B. Case, K. Kramer, E. Armstrong, L. Myers, A. Trivette, C. Gainza, R. Nargi, C. Selverian, E. Davidson, B. Doranz, , J. E. Crowe

The paper identifies a rare antibody that targets the SARS-CoV-2 spike trimer interface, disrupting viral entry and providing protection in mice.

bioRxiv · Jan 12, 2022Immunology

Neutralization Fingerprinting Technology for Characterizing Polyclonal Antibody Responses to Dengue Vaccines

N. Raju, X. Zhan, S. Das, L. Karwal, H. Dean, J. E. Crowe, R. H. Carnahan, I. Georgiev

This study presents a computational framework to analyze neutralizing antibody specificities in response to dengue vaccines, revealing differences in immune responses based on prior infection status.

bioRxiv · Dec 2, 2021Immunology

Elicitation of neutralizing antibody responses to HIV-1 immunization with nanoparticle vaccine platforms

A. A. Murji, J. S. Qin, T. Hermanus, L. Morris, I. Georgiev

This study evaluates two nanoparticle vaccine strategies to elicit broadly neutralizing antibodies against HIV-1 by incorporating Env diversity from clade A and C strains, showing neutralization in mice and guinea pigs.

bioRxiv · Jun 3, 2021Immunology