Author

S. F. Tavazoie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

B. N. Ostendorf· 2 shared H. Goodarzi· 2 shared J. M. Loo· 2 shared N. Adaku· 2 shared N. Yamaguchi· 2 shared A. Barlas· 1 shared A. Cercek· 1 shared A. E. Hendifar· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

B. N. Ostendorf

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

G. P. Donaldson, G. L. Reis, M. Saad, C. Wichmann, I. Mamede, G. Chen, C. E. Harrer, N. L. DelGaudio, D. Zhang, B. Aydin, T. B. R. Castro, S. Grivennikov, B. S. Reis, E. Liu, S. C. Eisenbarth, , D. Mucida

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

bioRxiv · Oct 6, 2023 · PreprintImmunology

Apolipoprotein E2 Promotes Melanoma Growth, Metastasis, and Protein Synthesis via the LRP1 Receptor

N. Adaku, B. N. Ostendorf, S. F. Tavazoie

This study shows APOE2 promotes melanoma growth, metastasis, and protein synthesis via LRP1, contrasting previous findings on APOE4.

bioRxiv · Oct 3, 2022Cancer Biology

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

I. Kurth, N. Yamaguchi, C. Andreu-Agullo, H. S. Tian, S. Sridhar, S. Takeda, F. C. Gonsalves, J. M. Loo, A. Barlas, K. Manova-Todorova, R. Busby, J. C. Bendell, J. Strauss, M. Fakih, A. J. McRee, , S. F. Tavazoie

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

bioRxiv · Apr 26, 2021Cancer Biology

Two Isoleucyl tRNAs that Decode 'Synonymous' Codons Divergently Regulate Breast Cancer Progression

L. B. Earnest-Noble, D. Hsu, H. Asgharian, N. Mandayam, M. C. Passarelli, H. Goodarzi, S. F. Tavazoie

The paper shows that two isoleucyl tRNAs decode synonymous codons and have opposing effects on breast cancer progression by regulating translation of growth-promoting genes.

bioRxiv · Apr 22, 2021 · PreprintCancer Biology

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia

N. Yamaguchi, E. Weinberg, A. Nguyen, M. V. Liberti, H. Goodarzi, Y. Y. Janjigian, P. B. Paty, L. B. Saltz, T. P. Kingham, J. M. Loo, E. d. Stanchina, S. F. Tavazoie

This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.

bioRxiv · Nov 7, 2019Cancer Biology

Germline genetic determination of cancer progression and survival

B. N. Ostendorf, K. N. Tafreshian, N. Adaku, J. Bilanovic, B. Tavora, S. F. Tavazoie

This study identifies APOE germline variants as predictors of melanoma survival and progression, showing APOE2 reduces survival while APOE4 increases it, with mechanistic insights into immune and tumor cell behavior.

bioRxiv · Mar 13, 2019Cancer Biology