Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
A. Nolan, M. S. Zeden, C. Campbell, I. Kviatkovski, L. Urwin, R. M. Corrigan, A. Gründling, J. P. O'Gara
This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.
bioRxiv · Sep 1, 2022 · PreprintMicrobiology