P. D. Fey

Microbiota and metabolic adaptation shape Staphylococcus aureus virulence and antimicrobial resistance during intestinal colonization

This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.

Staphylococcus aureus skin colonization is mediated by SasG lectin variation

This study identifies SasG-II, a variant of the S. aureus surface protein, which binds to a broader range of ligands, enhancing its ability to colonize skin.

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

Mechanistic basis of staphylococcal interspecies competition for skin colonization

This study investigates the structural and functional basis of staphylococcal adhesion to skin and reveals cross-inhibition between S. epidermidis and S. aureus.

A Transducing Bacteriophage Infecting Staphylococcus epidermidis Contributes to the Expansion of aNovel Siphovirus Genus and Implies Genus is Inappropriate for Phage Therapy

The paper reports a novel siphovirus phage infecting Staphylococcus epidermidis that can transduce antibiotic resistance, suggesting the genus is unsuitable for phage therapy.

Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production

This study identifies glutamine and glutamate transporters in S. aureus and shows their impact on c-di-AMP production and growth in rich medium.