Author

L. Urwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:zebrafish· 1

Frequent Co-Authors

L. J. Partridge· 2 shared L. R. Green· 2 shared P. N. Monk· 2 shared R. M. Corrigan· 2 shared A. Gründling· 1 shared A. Nolan· 1 shared B. Ciani· 1 shared B. Salamaga· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

L. J. Partridge

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection

N. R. Choudhury, L. Urwin, B. Salamaga, L. Prince, S. Renshaw, R. M. Corrigan

This study uses a zebrafish model to show that the stringent response, mediated by (p)ppGpp synthetases, is critical for S. aureus virulence and survival within host phagocytes.

bioRxiv · Jul 12, 2023 · PreprintMicrobiology

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

L. R. Green, R. Issa, F. Albaldi, L. Urwin, H. Khalid, C. E. Turner, B. Ciani, L. J. Partridge, P. N. Monk

This study shows CD9 and syndecan-1 cooperate for staphylococcal adhesion, with fibronectin also playing a role, and suggests CD9-targeted therapies could block bacterial entry.

bioRxiv · Jan 17, 2023Microbiology

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics

A. Nolan, M. S. Zeden, C. Campbell, I. Kviatkovski, L. Urwin, R. M. Corrigan, A. Gründling, J. P. O'Gara

This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.

bioRxiv · Sep 1, 2022 · PreprintMicrobiology

ACE2-independent interaction of SARS-CoV-2 spike protein to human epithelial cells can be inhibited by unfractionated heparin

L. J. Partridge, L. Urwin, M. J. Nicklin, D. C. James, L. R. Green, P. N. Monk

This paper shows that SARS-CoV-2 spike protein can interact with human cells without ACE2 and that unfractionated heparin inhibits this interaction.

Cells · Jun 7, 2021Peer-reviewedMicrobiology