S. Upadhyayula

Neural space-time model for dynamic scene recovery in multi-shot computational imaging systems

The paper introduces a neural space-time model to recover dynamic scenes in multi-shot computational imaging systems by jointly estimating the scene and its motion, reducing motion artifacts.

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

Torques within and outside the human spindle balance twist at anaphase

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

Characterization, Comparison, and Optimization of Lattice Light Sheets

This paper compares and optimizes lattice light sheets to improve resolution and reduce photobleaching in light sheet microscopy.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

Rescue of stalled clathrin-mediated endocytosis by asymmetric Arp2/3-mediated actin assembly

The paper investigates how asymmetric actin assembly rescues stalled clathrin-mediated endocytosis by analyzing endocytic dynamics and protein geometry using advanced imaging and computational methods.

An in-vitro BBB-on-a-chip open model of human blood-brain barrier enabling advanced optical imaging

The paper describes an in-vitro BBB-on-a-chip model that enables high-resolution imaging of blood-brain barrier dynamics.

Adherens junction serves to generate cryptic lamellipodia required for collective migration of epithelial cells

The paper investigates how adherens junctions generate cryptic lamellipodia in epithelial cells, enabling collective migration by recruiting actin regulators and facilitating follower cell trailing.

A highly homogeneous expansion microscopy polymer composed of tetrahedron-like monomers

This paper introduces a new expansion microscopy polymer with a more homogeneous network structure, achieving higher resolution and reduced spatial errors in imaging.

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.