Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs
N. A. Dawson, I. Rosado Sanchez, G. Novakovsky, V. Fung, Q. Huang, E. McIver, G. Sun, J. Gillies, M. Speck, P. C. Orban, M. Mojibian, M. K. Levings
This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.
bioRxiv · Aug 29, 2019Immunology