Author

G. Novakovsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. K. Levings· 2 shared C. L. Mackall· 1 shared C. Lamarche· 1 shared C. N. Qi· 1 shared E. McIver· 1 shared E. W. Weber· 1 shared G. Sun· 1 shared I. Rosado Sanchez· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

M. K. Levings

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2 papers

Recent·Most cited

Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion

C. Lamarche, G. Novakovsky, C. N. Qi, E. W. Weber, C. L. Mackall, M. K. Levings

This study shows that human regulatory T cells (Tregs) can become exhausted through repetitive stimulation or tonic-signaling CARs, reducing their suppressive function in vivo.

bioRxiv · Jun 27, 2020 · PreprintImmunology

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

N. A. Dawson, I. Rosado Sanchez, G. Novakovsky, V. Fung, Q. Huang, E. McIver, G. Sun, J. Gillies, M. Speck, P. C. Orban, M. Mojibian, M. K. Levings

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.

bioRxiv · Aug 29, 2019Immunology