Author

Ian Chen

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Amy L. BrewsteriD· 1 shared Benjamin Zirkle· 1 shared Brody A. DemingiD· 1 shared C. Max OtterbacheriD· 1 shared Chongli YuaniD· 1 shared Hope Elizabeth Harlow· 1 shared Jean‐Christophe RochetiD· 1 shared Jiaxiang WuiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Amy L. BrewsterORCID

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1 paper

Recent·Most cited

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

Zhefu Que, Maria I. Olivero-Acosta, Morgan J. Robinson, Ian Chen, Jingliang Zhang, Kyle W. Wettschurack, Jiaxiang Wu, Tiange Xiao, C. Max Otterbacher, Vinayak Shankar, Hope Elizabeth Harlow, Seoyong Hong, Benjamin Zirkle, Muhan Wang, Ningren Cui, , Yang Yang

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

Journal of Neuroscience · Nov 18, 2024Peer-reviewedNeuroscience