Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells
Yoseph W. Dance, Alice Amitrano, Annaka M. Saffron, Chanhong Min, Ladaisha T. Thompson, Zhuoxu Ge, Ian Michael Smith, Nicolas C. Macaluso, Charles Ezenwanne, Nicholas Milcik, Abigail Fennell, Kendall A. Pyndell, Kimberly M. Stroka, Jeremy D Walston, Sean X. Sun, , Jude M. Phillip
This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.
bioRxiv · Jan 14, 2026 · PreprintBioengineering