Molecular basis of autoimmune disease protection by MDA5 variants
Rahul Singh, Joe D. Joiner, Alba Herrero del Valle, Marleen Zwaagstra, Ida Jobe, Brian J. Ferguson, Frank J. M. van Kuppeveld, Yorgo Modis
This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.
Cell Reports · May 30, 2025Peer-reviewedBiochemistry