Author

Rahul Singh

MRC Laboratory of Molecular BiologyORCID 0000-0001-8397-0202Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rahul Singh2 papers · Chitkara University

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:fine-mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Yorgo ModisiD· 3 shared Alba Herrero del ValleiD· 2 shared Brian J. FergusoniD· 1 shared Chase P. BroedersziD· 1 shared Chris WallaceiD· 1 shared David DuliniD· 1 shared Flavia Stal PapiniiD· 1 shared Frank J. M. van KuppeveldiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Yorgo ModisORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicineBMC Medical GenomicsPeer-reviewedJun 2, 2025

MDA5 variants trade antiviral activity for protection from autoimmune disease

Chris Wallace, Rahul Singh, Yorgo Modis

The paper identifies MDA5 variants that protect against autoimmune diseases but increase IBD risk, showing a trade-off between antiviral activity and autoimmunity.

3 citations

humanGWAS summary statistics

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BiochemistryCell ReportsPeer-reviewedMay 30, 2025

Molecular basis of autoimmune disease protection by MDA5 variants

Rahul Singh, Joe D. Joiner, Alba Herrero del Valle…·Yorgo Modis

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

9 citations

humanproteomics

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BiophysicsbioRxivPreprintAug 27, 2024

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

Salina Quack, Sourav Maity, Pim P. B. America…·David Dulin

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.

1 citation

experimental assayhost-pathogen & immune response

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