Alba Herrero del Valle

This study reveals the structural basis and evolutionary origin of the Lamassu bacterial immune system, showing its adaptation from DNA repair machinery to detect and respond to viral replication.

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.

The paper investigates how the TnaC-ribosome complex recognizes and responds to L-Trp, revealing a mechanism involving cleavage rates and ligand binding.