Author

Marleen Zwaagstra

Utrecht UniversityORCID 0000-0002-6774-1503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Frank J. M. van KuppeveldiD· 3 shared Arno L. W. van Vliet· 2 shared Chiara Aloise· 2 shared Jelle G. Schipper· 2 shared Alain van MiliD· 1 shared Alba Herrero del ValleiD· 1 shared Bob J. IgnacioiD· 1 shared Brian J. FergusoniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Frank J. M. van KuppeveldORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection

Lonneke V. Nouwen, Esther A. Zaal, Inge Buitendijk, Marleen Zwaagstra, Chiara Aloise, Arno L. W. van Vliet, Jelle G. Schipper, Alain van Mil, Celia R. Berkers, Frank J. M. van Kuppeveld

This study identifies picornavirus proteins that inhibit de novo nucleotide synthesis during infection using metabolomics and recombinant virus analysis.

PLoS Pathogens · Jul 3, 2025Peer-reviewedMicrobiology

Molecular basis of autoimmune disease protection by MDA5 variants

Rahul Singh, Joe D. Joiner, Alba Herrero del Valle, Marleen Zwaagstra, Ida Jobe, Brian J. Ferguson, Frank J. M. van Kuppeveld, Yorgo Modis

This study investigates how autoimmune-protective MDA5 variants affect RNA sensing and signaling, finding they reduce interferon response and alter filament formation and ATP hydrolysis.

Cell Reports · May 30, 2025Peer-reviewedBiochemistry

The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses.

Jelle G. Schipper, Chiara Aloise, Sereina O. Sutter, Marleen Zwaagstra, Arno L. W. van Vliet, Rana Abdelnabi, Bob J. Ignacio, Kimberly M. Bonger, Dagmar Roelofs, Judith M. A. van den Brand, Richard Wubbolts, Lucas J. M. Bruurs, Hendrik Jan Thibaut, Johan H. Neyts, Marvin E. Tanenbaum, Frank J. M. van Kuppeveld

This study demonstrates that enterovirus 2A protease is critical for viral replication and evasion of host antiviral responses through multiple mechanisms.

bioRxiv · Feb 20, 2025 · PreprintMicrobiology