Michael N. Hall

Antizyme regulates polyamine uptake via ATP13A3

The paper identifies ATP13A3 as a plasma membrane polyamine transporter regulated by antizyme, showing that polyamine elevation leads to transporter internalization and reduced uptake.

Proteomics of Transglutaminase 2 polyaminated proteins

The paper identifies 51 protein targets modified by polyamines through transglutaminase 2, with modifications occurring on 66 sites, many involved in translation, cytoskeletal organization, or cancer.

SMG6-dependent RNA decay maintains dsRNA homeostasis and restrains immunogenicity in hepatocellular carcinoma

This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.

TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes

The paper shows that TORC1 inhibits Stm1 to reactivate dormant ribosomes, revealing an evolutionarily conserved mechanism for ribosome preservation.

Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model

The paper introduces bnClustOmics, a Bayesian network mixture model for multi-omics clustering, identifies three HCC subtypes with survival associations, and learns cluster-specific molecular networks.

Patterns of selection reveal shared molecular targets over short and long evolutionary timescales

The paper investigates how standing and de novo genetic variants contribute to drug adaptation in yeast, finding they act on shared molecular targets but via different mechanisms.