Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer
Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova, Agnieszka Będzińska, Damian Robert Sojka, Aneta Zebrowska, Marta Gawin, Maren Soldierer, Malwina Rist, Daniel Fochtman, Irem Ozel, Bernd Giebel, Iris Helfrich, Ilona Thiel, , Jadwiga Jabłońska
This study shows tumor-derived extracellular vesicles containing serpins A1/A3 reprogram neutrophils to support tumor growth by extending their lifespan and suppressing CD8 T cells.
bioRxiv · Mar 6, 2025 · PreprintCancer Biology