Author

Ekaterina Pylaeva

Essen University HospitalORCID 0000-0002-3941-9664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jadwiga JabłońskaiD· 3 shared Bente SiebelsiD· 2 shared Daniel Robert EngeliD· 2 shared Devon SiemesiD· 2 shared Giebel BerndiD· 2 shared Hartmut SchlüteriD· 2 shared Olga ShevchukiD· 2 shared Oliver SoehnleiniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Jadwiga JabłońskaORCID

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3 papers

Recent·Most cited

Integrated kidney and urine proteomics define encrypted antimicrobial peptides as effectors of host defence in human pyelonephritis

Lars Borgards, Hannah Voß, Stephanie Tautges, Bente Siebels, Ekaterina Pylaeva, Philippa Spangenberg, Devon Siemes, Christoph Krisp, Jessica Schmitz, Lisa Cinkul, Damilola Emmanuel Akinyemi, Annika Hilger, Paulina Szymczak, Anne-Christine Aust, Jan Hinrich Braesen, , Olga Shevchuk

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

bioRxiv · Apr 14, 2026 · PreprintImmunology

Histone neutralization protects the ischemic brain against stroke-associated pneumonia

Dongpei Yin, Anran Li, Olga Shevchuk, Ayan Mohamud Yusuf, Janine Gronewold, Stephanie Thiebes, Tobias Tertel, Chen Wang, Nina Hagemann, Yiqiao Zhang, Claudia Graser, Humeyra Tas, Michael Fleischer, Britta Kaltwasser, Benedikt Frank, , Dirk Matthias Hermann

This study shows that neutralizing extracellular histones reduces secondary brain injury and improves recovery after ischemic stroke complicated by pneumonia.

bioRxiv · Mar 3, 2026 · PreprintNeuroscience

Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer

Maksim Domnich, Ekaterina Pylaeva, Elena Siakaeva, Nastassia Kabankova, Agnieszka Będzińska, Damian Robert Sojka, Aneta Zebrowska, Marta Gawin, Maren Soldierer, Malwina Rist, Daniel Fochtman, Irem Ozel, Bernd Giebel, Iris Helfrich, Ilona Thiel, , Jadwiga Jabłońska

This study shows tumor-derived extracellular vesicles containing serpins A1/A3 reprogram neutrophils to support tumor growth by extending their lifespan and suppressing CD8 T cells.

bioRxiv · Mar 6, 2025 · PreprintCancer Biology