Human Gut Bacteria Convert Endogenous Steroids into Host Cortisol Shuttle Inhibitors
Seraina O. Moser, Jasmine T. Walsh, Philipp M. Späne, Taina Härkönen, Marianne Lalli, Ines Zalosnik, Denise V. Winter, Junehee Park, Marina V. Magicheva-Gupta, Megan D. McCurry, David J. Morris, Ye‐Ji Bang, Jun R. Huh, Perry A. Labelle, Andrew Tan Chan, , A. Sloan Devlin
The paper identifies gut bacteria-produced metabolites that inhibit HSD11B2, altering cortisol signaling and linking microbiome activity to blood pressure regulation.
bioRxiv · Aug 22, 2026 · PreprintMicrobiology