Cell type-focused compound screen in human organoids reveals CK1 and MAPK11 inhibition protects cone photoreceptors from death
Stefan Erich Spirig, Álvaro Herrero-Navarro, Larissa Utz, Valeria J. Arteaga-Moreta, Zoltán Raics, Susana Posada-Céspedes, Stéphanie Chreng, Olaf Galuba, Inga Galuba, Isabelle Claerr, Steffen Renner, Miklos Boldogkoi, Verónica Moreno‐Juan, P. Timo Kleindienst, Adrienn Volak, , Botond Roska
The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.
Neuron · Mar 30, 2026Peer-reviewedNeuroscience