Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15
Jinhai Yu, Tong Guo, Arun K. Das Gupta, Ernesto M. Llano, Thomas Salisbury, Naureen Wajahat, Dianne Zhao, Sean Slater, Qing Deng, Esra A. Akbay, Beverly A. Rothermel, John Michael Shelton, Bret M. Evers, Zhidan Wu, Iphigenia Tzameli, , Rodney Elwood Infante
This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.
Nature Communications · Jan 30, 2026Peer-reviewedCancer Biology