A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
Omnia M. Elsharkasy, Charlotte V. Hegeman, Tom A. P. Driedonks, Xiuming Liang, Ivana Lansweers, Olaf L. Cotugno, Ingmar Y. de Groot, Zoë E. M. N. J. de Wit, Antonio Garcia-Guerra, Niels J. A. Moorman, Sjoerd H. Boonstra, Esmeralda Bosman, Juliet W. Lefferts, Willemijn S. de Voogt, Jerney J. Gitz-Francois, , Olivier G. de Jong
This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.
Nature Communications · Nov 21, 2025Peer-reviewedMolecular Biology