Olivier G. de Jong

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

This paper develops hPep-based nanoparticles for efficient delivery of gene editors across multiple cell types, achieving high editing efficiency in human cells.

This paper introduces CRISPR MiRAGE, a miRNA-sensing guide RNA system that enables tissue-specific gene editing by modulating CRISPR activity based on miRNA signatures.

This study identifies novel drug treatments for spinal muscular atrophy by integrating multi-omics data and drug perturbation profiles, showing harmine improves disease phenotypes in models.